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Single-Cell Analyses of Heterotopic Ossification: Characteristics of Injury-Related Senescent Fibroblasts

1 Sept 2022

Abstract excerpt

Introduction: Injury-related cellular senescence may be involved in heterotopic ossification, and no research has been performed about this before. Methods and Results: The study utilized integrated single-cell RNA-sequencing (scRNA-seq) data from heterotopic ossification samples. The number of senescent cells increased from day 3 and reached the highest level at day 21. However, the expression level of Cyclin...

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PMID: 36185637
DOI: 10.2147/jir.s369376

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