Article

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

2023-04-16

Abstract excerpt

Osteoarthritis (OA) is one of the most common causes of physical disability among older people and its incidence increases with age. Removal of the senescent cells (SNCs) delays OA pathologies, but little is known about the SNCs in OA synovium and their roles in OA pathogenesis. Here, we reported that RCAN1 + IL1α + double-positive cells represent a senescent subset of synovial fibroblasts which accelerate carti...

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Literature Corpus work: 2992038c-f85a-5d4a-8584-3049bc44413b
DOI: 10.1101/2023.04.15.537012

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