Article

Sex differences in senescence burden within human osteoarthritic synovial fibroblasts

2026-08-17

Abstract excerpt

<h4>Objective</h4> Cellular senescence has been shown to underlie many age-related diseases, including osteoarthritis (OA). In addition to age, biological sex is an OA risk factor with females at greater risk of hand and knee OA. We profiled the senescence burden in OA human synovial fibroblasts while accounting for these factors to understand how senescence may contribute to the increased burden of OA in females...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8274dfe-7058-588b-be6d-67aff0c2baf2
DOI: 10.64898/2026.08.14.744916

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex differences in senescence burden within human osteoarthritic synovial fibroblastsDOI 10.64898/2026.08.14.744916Read

Cellular senescence in osteoarthritis pathologySemantic proximity Read

Development of Reliable and High‐Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment OptionsSemantic proximity Read

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritisSemantic proximity Read

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4-α5β1 Axis.Semantic proximity Read

Screening of Biomarkers Associated with Osteoarthritis Aging Genes and Immune Correlation StudiesSemantic proximity Read

How are Aging and Osteoarthritis Related?Semantic proximity Read

Cellular senescence in skeletal diseases: A bibliometric analysis from 2007 to 2024Semantic proximity Read

Transcriptomic changes during the replicative senescence of human articular chondrocytesSemantic proximity Read

Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes.Semantic proximity Read

Single Cell Analysis Dissects the Effects of Vitamin D on Genetic Senescent Signatures Across Murine TissuesSemantic proximity Read

Cellular Senescence in Health, Disease, and Lens AgingSemantic proximity Read

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritisSemantic proximity Read