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Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones

18 Jul 2025

Abstract excerpt

Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenitor cells (MDSPCs) during OA progression, aiming to identify potential therapeutic targets. Histopathological evaluations and...

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PMID: 40680126
DOI: 10.1126/sciadv.adu2294

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