Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population.

doi:10.1161/CIRCGEN.125.005298

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population.

Circulation. Genomic and precision medicine - 1 Aug 2026

Kim Daeeun, Polikowsky Hannah G, Highland Heather M, Chen Hung-Hsin, Zhu Wanying, Zhang Xinruo, Gillman Madeline G, Frankel Elizabeth G, Roshani Rashedeh, Landman Joshua M, Wang Yujie, Young Kristin L, Anwar Mohammad Yaser, Krishnan Mohanraj, Buchanan Victoria L, Berndt Sonja I, Arias Joshua D, Raffield Laura M, Gutierrez Absalon D, Bishehsari Faraz, Lee Miryoung, McCormick Joseph B, Fisher-Hoch Susan P, Below Jennifer E, North Kari E, Graff Mariaelisa

Abstract excerpt

BACKGROUND: While GWAS (genome-wide association studies) have identified over 1000 obesity-associated loci, their functional impact on gene expression remains unclear. Moreover, many studies have not fully captured the genetic architecture of obesity in high-risk populations or considered the complexity of adiposity beyond traditional measures. To address these gaps, this study explores the genetic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Hispanic or Latino

Share to Obesity

Share to Period Circadian Proteins

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 42037308
DOI: 10.1161/CIRCGEN.125.005298
PMCID: PMC13127804

Genes

MAPK11
PER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population.PMID 42037308Read ↗

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signaturesSemantic proximity Read ↗

A Complex Network of Obesity-Risk Genes Revealed by Systematic Bioinformatics and Single-Cell Transcriptomic Analyses.Semantic proximity Read ↗

Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.Semantic proximity Read ↗

Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes.Semantic proximity Read ↗

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.Semantic proximity Read ↗

Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity.Semantic proximity Read ↗

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetesSemantic proximity Read ↗

Deciphering the genetic landscape of obesity: a data-driven approach to identifying plausible causal genes and therapeutic targets.Semantic proximity Read ↗

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.Semantic proximity Read ↗

Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)Semantic proximity Read ↗

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.Semantic proximity Read ↗

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.