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Article

Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture.

Journal of diabetes - 1 Apr 2026

Lu Chuanlong, Li Lizheng, Chen Jinshan, Chang Runze, Dong Honglin

Abstract excerpt

BACKGROUND: The genetic basis of cardiovascular-kidney-metabolic syndrome (CKMs) involves complex pleiotropy, necessitating analytical approaches capable of dissecting shared genetic architectures across multiple cardiometabolic traits. METHODS: We employed genomic structural equation modeling (genomic SEM) to integrate summary statistics from six cardiometabolic traits. The model was assessed using standard fit...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41974591
DOI: 10.1111/1753-0407.70225
PMCID: PMC13076060

Genes

CFI
GC
GCKR
JAZF1
KIF11
SENP2
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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