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Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture.

Journal of diabetes - 1 Apr 2026

Lu Chuanlong, Li Lizheng, Chen Jinshan, Chang Runze, Dong Honglin

Abstract excerpt

BACKGROUND: The genetic basis of cardiovascular-kidney-metabolic syndrome (CKMs) involves complex pleiotropy, necessitating analytical approaches capable of dissecting shared genetic architectures across multiple cardiometabolic traits. METHODS: We employed genomic structural equation modeling (genomic SEM) to integrate summary statistics from six cardiometabolic traits. The model was assessed using standard fit...

Topics

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Cardiovascular Diseases
Genome-Wide Association Study
Genomics
Kidney Diseases
Metabolic Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Multifactorial Inheritance

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41974591
DOI: 10.1111/1753-0407.70225
PMCID: PMC13076060

Genes

CFI
GC
GCKR
JAZF1
KIF11
SENP2
TCF7L2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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