Article
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome.
Nature genetics - 1 Nov 2024
Park Sanghyeon, Kim Soyeon, Kim Beomsu, Kim Dan Say, Kim Jaeyoung, Ahn Yeeun, Kim Hyejin, Song Minku, Shim Injeong, Jung Sang-Hyuk, Cho Chamlee, Lim Soohyun, Hong Sanghoon, Jo Hyeonbin, Fahed Akl C, Natarajan Pradeep, Ellinor Patrick T, Torkamani Ali, Park Woong-Yang, Yu Tae Yang, Myung Woojae, Won Hong-Hee
Abstract excerpt
Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe...
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