APOL1 kidney risk variants and outcomes in children with congenital anomalies of the kidney and urinary tract.

doi:10.1007/s00467-025-07127-z

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Article

APOL1 kidney risk variants and outcomes in children with congenital anomalies of the kidney and urinary tract.

Pediatric nephrology (Berlin, Germany) - 1 Jun 2026

Vendrig Lisanne M, Ke Juntao, Tanck Michael W T, Lim Tze Y, Martinelli Elena, Bodria Monica, Capone Valentina, Izzi Claudia, La Scola Claudio, Maggiore Umberto, Marzuillo Pierluigi, Masnata Giuseppe, Mentch Frank D, Montini Giovanni, Pisani Isabella, Qu Huiqi, Sampson Matthew G, Simões-E-Silva Ana Cristina, Thomas Alexandria, Groothoff Jaap W, Hakonarson Hakon, Ghiggeri Gian Marco, Verbitsky Miguel, Levtchenko Elena N, Sanna-Cherchi Simone, Westland Rik

Abstract excerpt

BACKGROUND: APOL1 high-risk variants predispose to chronic kidney disease (CKD) in individuals of African genetic ancestry due to podocyte toxicity. As congenital anomalies of the kidney and urinary tract (CAKUT) have variable outcomes potentially driven by podocyte injury, we hypothesize that the outcome of children with CAKUT is influenced by APOL1 risk genotypes. METHODS: APOL1 risk status was determined in...

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PMID: 41535652
DOI: 10.1007/s00467-025-07127-z
PMCID: PMC13359541

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APOL1

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