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A focus on the association of Apol1 with kidney disease in children.

Pediatric nephrology (Berlin, Germany) - 1 Apr 2021

Ekulu Pepe M, Nkoy Agathe B, Adebayo Oyindamola C, Kazadi Orly K, Aloni Michel N, Arcolino Fanny O, Ngiyulu Rene M, Gini Jean-Lambert E, Lepira François B, Van den Heuvel Lamberthus P, Levtchenko Elena N

Abstract excerpt

Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been...

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PMID: 32253519
DOI: 10.1007/s00467-020-04553-z

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