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Article

APOL1 Nephropathy: From Genetics to Clinical Applications.

Clinical journal of the American Society of Nephrology : CJASN - 8 Feb 2021

Friedman David J, Pollak Martin R

Abstract excerpt

Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32616495
DOI: 10.2215/CJN.15161219
PMCID: PMC7863644

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