Article
APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2017
Ng Derek K, Robertson Catherine C, Woroniecki Robert P, Limou Sophie, Gillies Christopher E, Reidy Kimberly J, Winkler Cheryl A, Hingorani Sangeeta, Gibson Keisha L, Hjorten Rebecca, Sethna Christine B, Kopp Jeffrey B, Moxey-Mims Marva, Furth Susan L, Warady Bradley A, Kretzler Matthias, Sedor John R, Kaskel Frederick J, Sampson Matthew G
Abstract excerpt
BACKGROUND: Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The role of APOL1 risk genotypes in children with glomerular disease is less...
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