Article
Epigenetic and Cellular Diversity in the Brain through Allele-Specific Effects.
Trends in neurosciences - 1 Dec 2018
Huang Wei-Chao, Bennett Kathleen, Gregg Christopher
Abstract excerpt
The benefits of diploidy are considered to involve masking partially recessive mutations and increasing genetic diversity. Here, we review new studies showing evidence for diverse allele-specific expression and epigenetic states in mammalian brain cells, which suggest that diploidy expands the landscape of gene regulatory and expression programs in cells. Allele-specific expression has been thought to be...
Topics
- Alleles
- Animals
- Brain
- Diploidy
- Epigenomics
- Gene Expression Regulation
- Humans