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Article

Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR.

Multiple sclerosis and related disorders - 1 Jun 2020

Pistono Cristiana, Monti Maria Cristina, Marchesi Nicoletta, Boiocchi Chiara, Campagnoli Lucrezia Irene Maria, Morlotti Danila, Cuccia Mariaclara, Govoni Stefano, Montomoli Cristina, Mallucci Giulia, Bergamaschi Roberto, Pascale Alessia

Abstract excerpt

BACKGROUND: ELAV-like proteins are a small family of RNA-binding proteins that are fundamental players in post-transcriptional mechanisms and are involved in the pathogenesis of neurologic and psychiatric disorders. HuR, the ubiquitously expressed member of the family, is also implicated in sustaining inflammation and inflammatory diseases, supporting the production of pro-inflammatory cytokines. Inflammation...

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PMID: 32200342
DOI: 10.1016/j.msard.2020.102048

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