Article

Disrupting miR-466l-3p and HuR Cooperation with Target Site Blockers Reveals a Therapeutic Strategy to Destabilize mRNA Transcripts

2026-04-01

Abstract excerpt

MicroRNAs (miRNAs) typically regulate gene expression by promoting mRNA degradation, but select miRNAs, such as miR-466l-3p (miR-466), can instead stabilize transcripts in coordination with RNA-binding proteins (RBPs) like HuR. We identify conserved AU-rich elements (cAREs) within the 3'-UTRs of IL-17A, GM-CSF, and IL-23A as critical cis-regulatory binding site where miR-466 facilitates HuR recruitment to promote...

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Literature Corpus work: 0fd1d37a-9d75-53fb-87e6-35e66145d193
DOI: 10.64898/2026.03.30.709388

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