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Article

Structural basis for the subtype-selectivity of KCa2.2 channel activators.

Nature communications - 8 Jan 2026

Nam Young-Woo, Ramanishka Alena, Xu Yang, Yasuda Rose Marie Haynes, Nasburg Joshua A, Im Dohyun, Cui Meng, Chandy K George, Wulff Heike, Zhang Miao

Abstract excerpt

Small-conductance (KCa2.2) and intermediate-conductance (KCa3.1) Ca2+-activated K+ channels are gated by a Ca2+-calmodulin dependent mechanism. NS309 potentiates the activity of both KCa2.2 and KCa3.1, while rimtuzalcap selectively activates KCa2.2. Rimtuzalcap has been used in clinical trials for the treatment of spinocerebellar ataxia and essential tremor. We report cryo-electron microscopy structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41507196
DOI: 10.1038/s41467-025-67232-3
PMCID: PMC12804778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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