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Article

Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.

Structure (London, England : 1993) - 3 Jul 2012

Wang Chaojian, Chung Ben C, Yan Haidun, Lee Seok-Yong, Pitt Geoffrey S

Abstract excerpt

Voltage-gated Na⁺ (Na(V)) channels initiate neuronal action potentials. Na(V) channels are composed of a transmembrane domain responsible for voltage-dependent Na⁺ conduction and a cytosolic C-terminal domain (CTD) that regulates channel function through interactions with many auxiliary proteins, including fibroblast growth factor homologous factors (FHFs) and calmodulin (CaM). Most ion channel structural studies...

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Identifiers

PMID: 22705208
DOI: 10.1016/j.str.2012.05.001
PMCID: PMC3610540

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Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.PMID 22705208Read ↗

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