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Article

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels.

Acta pharmacologica Sinica - 1 Feb 2023

Nam Young-Woo, Downey Myles, Rahman Mohammad Asikur, Cui Meng, Zhang Miao

Abstract excerpt

Small- and intermediate-conductance Ca2+-activated K+ (KCa2.x/KCa3.1 also called SK/IK) channels are gated exclusively by intracellular Ca2+. The Ca2+ binding protein calmodulin confers sub-micromolar Ca2+ sensitivity to the channel-calmodulin complex. The calmodulin C-lobe is constitutively associated with the proximal C-terminus of the channel. Interactions between calmodulin N-lobe and the channel S4-S5 linker...

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Identifiers

PMID: 35715699
DOI: 10.1038/s41401-022-00935-1
PMCID: PMC9889811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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