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Article

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid-Induced Neurotoxic Phenotype of Astrocytes.

Glia - 1 Mar 2026

Esteve Daniel, Bresque Mariana, Okhuevbie Daniel, Ramachandran Sandhya, Pehar Mariana, Vargas Marcelo R

Abstract excerpt

Astrocytes are central to lipid metabolism in the central nervous system. Due to their morphological and functional characteristics, astrocytes can uptake fatty acids (FAs) from the bloodstream and extracellular space and store them in lipid droplets (LD). LD are dynamic organelles, whose accumulation in astrocytes has been shown to occur upon exposure to various stress stimuli. Different hypotheses proposed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41493797
DOI: 10.1002/glia.70136
PMCID: PMC12772936

Genes

LDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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