Article
Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity
2018-11-07
Abstract excerpt
Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic, peroxidated fatty acids (FAs) produced in hyperactive neurons are transferred to astrocytic lipid droplets by lipoprotein particles. Astrocytes consume the...
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Identifiers and source
- Literature Corpus work
- 3aa69b8f-e43b-5db0-b8d7-1d222c66c4b5
- DOI
- 10.1101/465237