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Article

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

Stem cell reports - 8 Aug 2017

Tripathi Pratibha, Rodriguez-Muela Natalia, Klim Joseph R, de Boer A Sophie, Agrawal Sahil, Sandoe Jackson, Lopes Claudia S, Ogliari Karolyn Sassi, Williams Luis A, Shear Matthew, Rubin Lee L, Eggan Kevin, Zhou Qiao

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease. Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. However, the role of astrocyte in promoting motor neuron protein aggregation, a disease hallmark of ALS, remains largely unclear. Here, using culture models of human motor neurons and primary astrocytes of different genotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28712846
DOI: 10.1016/j.stemcr.2017.06.008
PMCID: PMC5549875

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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