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Article

Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes.

Stem cell reports - 13 Jan 2026

Franklin Hannah D, Crerar Hamish, Parnandi Nishita, Lattke Michael, Majewski Stanislaw, Clarke Benjamin E, Pallikonda Husayn, Howell Michael, Boulton Simon J, Patani Rickie

Abstract excerpt

Astrocytes are essential regulators of neuronal health, and their dysfunction contributes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Using human induced pluripotent stem cell (iPSC)-derived astrocytes carrying ALS-associated VCP mutations, we uncover cell-autonomous activation of the hypoxia response under basal conditions. VCP-mutant astrocytes exhibit increased nuclear...

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Source

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Identifiers

PMID: 41349534
DOI: 10.1016/j.stemcr.2025.102723
PMCID: PMC12925969

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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