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Article

Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice.

Molecular and cellular neurosciences - 1 Oct 2018

Bakshi Rachit, Xu Yuehang, Mueller Kaly A, Chen Xiqun, Granucci Eric, Paganoni Sabrina, Sadri-Vakili Ghazaleh, Schwarzschild Michael A

Abstract excerpt

Dominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Oxidative stress has also been linked to many of the neurodegenerative diseases and is likely a central mechanism of motor neuron death in ALS. Astrocytes derived from mutant SOD1G93A mouse models or patients play a...

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Identifiers

PMID: 29928993
DOI: 10.1016/j.mcn.2018.06.002

Genes

SOD1

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