Article
Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants.
Cell - 9 Nov 2023
Rummel Christine K, Gagliardi Miriam, Ahmad Ruhel, Herholt Alexander, Jimenez-Barron Laura, Murek Vanessa, Weigert Liesa, Hausruckinger Anna, Maidl Susanne, Hauger Barbara, Raabe Florian J, Fürle Christina, Trastulla Lucia, Turecki Gustavo, Eder Matthias, Rossner Moritz J, Ziller Michael J
Abstract excerpt
Schizophrenia (SCZ) is a highly heritable mental disorder with thousands of associated genetic variants located mostly in the noncoding space of the genome. Translating these associations into insights regarding the underlying pathomechanisms has been challenging because the causal variants, their mechanisms of action, and their target genes remain largely unknown. We implemented a massively parallel variant...
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