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Article

Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk.

Neuron - 6 Nov 2024

Borcuk Christopher, Parihar Madhur, Sportelli Leonardo, Kleinman Joel E, Shin Joo Heon, Hyde Thomas M, Bertolino Alessandro, Weinberger Daniel R, Pergola Giulio

Abstract excerpt

The omnigenic model posits that genetic risk for traits with complex heritability involves cumulative effects of peripheral genes on mechanistic "core genes," suggesting that in a network of genes, those closer to clusters including core genes should have higher GWAS signals. In gene co-expression networks, we confirmed that GWAS signals accumulate in genes more connected to risk-enriched gene clusters,...

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PMID: 39236717
DOI: 10.1016/j.neuron.2024.08.005

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