Polygenic risk for psychiatric disorders and its association with neuropsychiatric symptoms in dementia.

doi:10.1080/09540261.2025.2600619

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Article

Polygenic risk for psychiatric disorders and its association with neuropsychiatric symptoms in dementia.

International review of psychiatry (Abingdon, England) - 1 Dec 2025

Najar Jenna, de Rojas Itziar, Dalmasso Maria Carolina, Fernandez Maria Victoria, de Boer Sterre C M, Ramirez Alfredo, Priller Josef, Laske Christoph, Kleineidam Luca, Schneider Anja, Wagner Michael, Heilmann-Heimbach Stefanie, Scherer Martin, Froelich Lutz, Peters Oliver, Hellmann-Regen Julian, Wiltfang Jens, Düzel Emrah, Buerger Katharina, Perneczky Robert, Teipel Stefan, Jessen Frank, Kornhuber Johannes, Lemstra Afina W, Pijnenburg Yolande A L, van der Lee Sven J, Reus Lianne M

Abstract excerpt

Neuropsychiatric symptoms are common in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), yet their genetic underpinnings remain unclear. To gain insight into biological processes related to neuropsychiatric symptoms in dementia, we investigated whether polygenic risk scores (PRS) for psychiatric disorders - major depressive disorder (MDD), schizophrenia (SCZ), bipolar...

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PMID: 41437785
DOI: 10.1080/09540261.2025.2600619

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