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Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in a Chinese Cohort.

Neuroscience bulletin - 1 Jul 2020

Li Wei-Wei, Wang Zhen, Fan Dong-Yu, Shen Ying-Ying, Chen Dong-Wan, Li Hui-Yun, Li Ling, Yang Heng, Liu Yu-Hui, Bu Xian-Le, Jin Wang-Sheng, Zeng Fan, Xu Zhi-Qiang, Yu Jin-Tai, Chen Li-Yong, Wang Yan-Jiang

Abstract excerpt

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer's disease (sAD) and pathological biomarkers in cerebrospinal fluid (CSF), 462 sAD patients and 463 age-matched cognitively normal (CN) controls were genotyped for 35 single-nucleotide polymorphisms (SNPs) that are significantly associated with sAD. Then, the alleles found to be associated with sAD were used to build polygenic...

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PMID: 32072450
DOI: 10.1007/s12264-020-00469-8
PMCID: PMC7340696

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