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Article

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks.

eLife - 9 Apr 2014

Tkach Karen E, Barik Debashis, Voisinne Guillaume, Malandro Nicole, Hathorn Matthew M, Cotari Jesse W, Vogel Robert, Merghoub Taha, Wolchok Jedd, Krichevsky Oleg, Altan-Bonnet Grégoire

Abstract excerpt

Variability within isogenic T cell populations yields heterogeneous 'local' signaling responses to shared antigenic stimuli, but responding clones may communicate 'global' antigen load through paracrine messengers, such as cytokines. Such coordination of individual cell responses within multicell...

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Identifiers

PMID: 24719192
DOI: 10.7554/eLife.01944
PMCID: PMC3980879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24719192-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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