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Article

A kinetic analysis of protein transport through the anthrax toxin channel.

The Journal of general physiology - 1 Jun 2011

Basilio Daniel, Kienker Paul K, Briggs Stephen W, Finkelstein Alan

Abstract excerpt

Anthrax toxin is composed of three proteins: a translocase heptameric channel, (PA(63))(7), formed from protective antigen (PA), which allows the other two proteins, lethal factor (LF) and edema factor (EF), to translocate across a host cell's endosomal membrane, disrupting cellular homeostasis. (PA(63))(7) incorporated into planar phospholipid bilayer membranes forms a channel capable of transporting LF and EF....

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21624946
DOI: 10.1085/jgp.201110627
PMCID: PMC3105512

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