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Article

Multistep protein unfolding during nanopore translocation.

Nature nanotechnology - 1 Apr 2013

Rodriguez-Larrea David, Bayley Hagan

Abstract excerpt

Cells are divided into compartments and separated from the environment by lipid bilayer membranes. Essential molecules are transported back and forth across the membranes. We have investigated how folded proteins use narrow transmembrane pores to move between compartments. During this process, the proteins must unfold. To examine co-translocational unfolding of individual molecules, we tagged protein substrates...

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Identifiers

PMID: 23474543
DOI: 10.1038/nnano.2013.22
PMCID: PMC4830145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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