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Article

Genetic diversity in melanomagenesis: a comprehensive analysis of BRAF, NRAS, KIT and novel mutations across melanoma subtypes.

BMC cancer - 17 Dec 2025

Göze Ömer Fahrettin, Buettner Reinhard, Odenthal Margarete, Heydt Carina

Abstract excerpt

BACKGROUND AND AIM: Melanomagenesis involves genetic alterations affecting multiple oncogenic pathways, with BRAF and NRAS mutations representing frequently studied drivers. Recent evidence suggests melanoma development encompasses a broader spectrum including KIT mutations and novel variants exhibiting population-specific patterns. This study aimed to characterize the genetic landscape of melanomagenesis by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41408518
DOI: 10.1186/s12885-025-15458-1
PMCID: PMC12888517

Genes

BRAF
KIT
NRAS
OXA1L
CDKN2A
KNSTRN
KRAS
NF1
PIK3CA
RAC1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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