Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study.

doi:10.1111/pcmr.13058

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Article

Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study.

Pigment cell & melanoma research - 1 Nov 2022

Luo Li, Shen Ronglai, Arora Arshi, Orlow Irene, Busam Klaus J, Lezcano Cecilia, Lee Tim K, Hernando Eva, Gorlov Ivan, Amos Christopher, Ernstoff Marc S, Seshan Venkatraman E, Cust Anne E, Wilmott James, Scolyer Richard A, Mann Graham, Nagore Eduardo, Funchain Pauline, Ko Jennifer, Ngo Peter, Edmiston Sharon N, Conway Kathleen, Googe Paul B, Ollila David, Lee Jeffrey E, Fang Shenying, Rees Judy R, Thompson Cheryl L, Gerstenblith Meg, Bosenberg Marcus, Gould Rothberg Bonnie, Osman Iman, Saenger Yvonne, Reynolds Adam Z, Schwartz Matthew, Boyce Tawny, Holmen Sheri, Brunsgaard Elise, Bogner Paul, Kuan Pei Fen, Wiggins Charles, Thomas Nancy E, Begg Colin B, Berwick Marianne

Abstract excerpt

It is unclear why some melanomas aggressively metastasize while others remain indolent. Available studies employing multi-omic profiling of melanomas are based on large primary or metastatic tumors. We examine the genomic landscape of early-stage melanomas diagnosed prior to the modern era of immunological treatments. Untreated cases with Stage II/III cutaneous melanoma were identified from institutions...

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PMID: 35876628
DOI: 10.1111/pcmr.13058
PMCID: PMC9640183

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