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Article

Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond.

Critical reviews in oncology/hematology - 1 Sept 2024

Colombino Maria, Casula Milena, Paliogiannis Panagiotis, Manca Antonella, Sini Maria Cristina, Pisano Marina, Santeufemia Davide Adriano, Cossu Antonio, Palmieri Giuseppe

Abstract excerpt

Melanoma pathogenesis, conventionally perceived as a linear accumulation of molecular changes, discloses substantial heterogeneity driven by non-linear biological processes, including the direct transformation of melanocyte stem cells. This heterogeneity manifests in diverse biological phenotypes and developmental states, influencing variable responses to treatments. Unveiling the aberrant mechanisms steering...

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Identifiers

PMID: 38977143
DOI: 10.1016/j.critrevonc.2024.104435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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