C620Y Mutation-Induced Destabilization of the Androgen Receptor Disrupts DNA Recognition Specificity in Prostate Cancer: Insights from Extensive Parametric Normal Mode Simulations.

Abstract excerpt

The rising surge of prostate cancer (PC) and its evolution to metastatic castration resistant prostate cancer (mCRPC) all around the globe, calls for a brisk treatment target characterization. Androgen receptor (AR) is a well-proclaimed mCRPC driver, identified in various mutant forms in PC samples. The mutation of a conserved cysteine in the DNA binding domain (DBD) of AR (C620Y) has been known to cause receptor...

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