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Article

Exploring the mechanism of a regulatory SNP of KLK3 by molecular dynamics simulation.

Journal of biomolecular structure & dynamics - 1 Apr 2013

Zhang Zhiyi, Liu Ming, Li Beiping, Wang Yuelan, Yue Junjie, Liang Long, Sun Jianzhong

Abstract excerpt

The SNP -158G>A of KLK3 has been validated as a regulatory SNP (rSNP) by molecular biology assays, but the mechanism of how it affects the binding of an androgen receptor (AR) homodimer with DNA is unclear. In the current study, molecular dynamics simulation was adopted to explain its inner cause...

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Source

Identifiers

PMID: 22877366
DOI: 10.1080/07391102.2012.703067

Genes

KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22877366-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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