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Genetic Variants in BER Pathway Genes Confer Wilms Tumor Susceptibility: New Insights from an Eight-Center Case-Control Study in Chinese Children.

Annals of surgical oncology - 1 Mar 2026

Zhu Sheng, Lai Jiahui, Lin Lei, Zhou Haixia, Wang Yizhen, Lu Hongting, Zhang Shouhua, He Shaohua, Zhou Chunlei, Liu Xun, He Jing, Hua Rui-Xi, Li Yong

Abstract excerpt

BACKGROUND: Wilms tumor is a highly heterogeneous tumor, and patients with high-risk Wilms tumor still do not have a good prognosis. DNA instability caused by abnormal genes in the base excision repair (BER) pathway is closely related to cancer. However, the important role of BER pathway gene variants in Wilms tumor remains largely unknown. METHODS: We enrolled 621 patients with Wilms tumor and 1737 controls from...

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Identifiers

PMID: 41400806
DOI: 10.1245/s10434-025-18911-4

Genes

FEN1
APEX1
XRCC1
TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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