Article
A genome-wide association study identifies susceptibility loci for Wilms tumor.
Nature genetics - 29 Apr 2012
Turnbull Clare, Perdeaux Elizabeth R, Pernet David, Naranjo Arlene, Renwick Anthony, Seal Sheila, Munoz-Xicola Rosa Maria, Hanks Sandra, Slade Ingrid, Zachariou Anna, Warren-Perry Margaret, Ruark Elise, Gerrard Mary, Hale Juliet, Hewitt Martin, Kohler Janice, Lane Sheila, Levitt Gill, Madi Mabrook, Morland Bruce, Neefjes Veronica, Nicholson James, Picton Susan, Pizer Barry, Ronghe Milind, Stevens Michael, Traunecker Heidi, Stiller Charles A, Pritchard-Jones Kathy, Dome Jeffrey, Grundy Paul, Rahman Nazneen
Abstract excerpt
Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10(-5) in two independent replication series from the UK (769 cases and 2,814 controls) and the United...
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