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Genetic variations in NER pathway gene polymorphisms and Wilms tumor risk: A six-center case-control study in East China.

IUBMB life - 1 Dec 2024

Zhan Xueli, Zhou Haixia, Deng Changmi, Hua Rui-Xi, Pan Lingling, Zhang Shouhua, Lu Hongting, He Shaohua, Wang Yizhen, Ruan Jichen, Zhou Chunlei, He Jing

Abstract excerpt

The nucleotide excision repair (NER) system is one of the main ways to protect organisms from DNA damage caused by endogenous and exogenous carcinogens. NER deficiency increases genome mutations, chromosomal aberrations, and cancer viability. However, the genetic association between Wilms tumor and NER pathway gene polymorphisms needs to be further validated. We assessed the associations between 19 NER gene...

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PMID: 39415460
DOI: 10.1002/iub.2919

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