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The contribution of WTAP gene variants to Wilms tumor susceptibility.

Gene - 5 Sept 2020

Ma Li, Hua Rui-Xi, Lin Huiran, Zhu Jinhong, Fu Wen, Lin Ao, Zhang Jiao, Cheng Jiwen, Zhou Haixia, Li Suhong, Zhuo Zhenjian, He Jing

Abstract excerpt

Wilms tumor is the most frequently occurring pediatric renal malignancy. Wilms tumor suppressor-1-associated protein (WTAP) is a vital component of N6-methyltransferase complex involved in tumorigenesis. However, the roles of WTAP gene single nucleotide polymorphisms (SNPs) in Wilms tumor risk have not been clarified to date. We successfully genotyped three WTAP gene SNPs using TaqMan assay in 405 Wilms tumor...

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PMID: 32504654
DOI: 10.1016/j.gene.2020.144839

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