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Article

Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

8 Aug 2018

Abstract excerpt

Nucleotide excision repair (NER) is an essential mechanism of the body to defend against exogenous carcinogen-induced DNA damage. Defects in NER may impair DNA repair capacity and, therefore, increase genome instability and cancer susceptibility. To explore genetic predispositions to Wilms tumor, we conducted a case-control study totaling 145 neuroblastoma cases and 531 healthy controls. We systematically...

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Identifiers

PMID: 30161024
DOI: 10.1016/j.omtn.2018.08.002

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