Article
LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study.
BMC cancer - 27 Jun 2024
Fu Wen, Deng Linqing, Yan Xiaosong, Hua Rui-Xi, Zhang Jiao, Zhou Haixia, Deng Changmi, Li Suhong, Cheng Jiwen, Ruan Jichen, He Jing, Liu Guochang
Abstract excerpt
BACKGROUND: Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the susceptibility to develop certain tumor types. Apart from LMO1, the LMO gene family members also include LMO2-4, each of which has oncogenic potential. METHODS: We conducted this five-center...
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