Genetic variations in the base excision repair pathway and susceptibility to Wilms tumor in eastern Chinese children: a six-center case-control study.

doi:10.1016/j.gene.2026.150316

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Article

Genetic variations in the base excision repair pathway and susceptibility to Wilms tumor in eastern Chinese children: a six-center case-control study.

Gene - 15 Nov 2026

Shao Bo, Zhou Chunlei, Zhou Haixia, Deng Changmi, Fang Yuan, Zhang Shouhua, Lu Hongting, He Shaohua, Hua Rui-Xi, Wang Yizhen

Abstract excerpt

BACKGROUND: Wilms tumor (WT) is the most common embryonal kidney cancer in children, and the base excision repair (BER) mechanism is crucial for repairing DNA damage from reactive oxygen species. Genetic polymorphisms in BER genes may impact cancer risk by affecting DNA repair capacity. METHODS: The research included 416 individuals with WT and 936 without the condition, examining 20 single nucleotide...

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Identifiers

PMID: 42462820
DOI: 10.1016/j.gene.2026.150316

Genes

FEN1
XRCC1
PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.