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Article

Aub, Vasa, and Armi concentration in phase-separated nuage is dispensable for piRNA biogenesis and transposon silencing.

RNA (New York, N.Y.) - 17 Feb 2026

Ho Samantha, Rice Nicholas P, Yu Tianxiong, Weng Zhiping, Theurkauf William E

Abstract excerpt

The piRNA biogenesis machinery localizes to phase-separated nuage granules, but nuage function is not well understood. We therefore assayed nuage composition, piRNA expression, and transposon silencing in Drosophila mutants that disrupt piRNA precursor production and nuclear export, ping-pong amplification, and phased piRNA biogenesis. These mutations destabilize the genome and activate Chk2 signaling, and...

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Identifiers

PMID: 41397877
DOI: 10.1261/rna.080801.125
PMCID: PMC12908453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Aub, Vasa, and Armi concentration in phase-separated nuage is dispensable for piRNA biogenesis and transposon silencing.PMID 41397877Read ↗

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