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Article

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.

Nature communications - 25 Aug 2020

Suen Kin Man, Braukmann Fabian, Butler Richard, Bensaddek Dalila, Akay Alper, Lin Chi-Chuan, Milonaitytė Dovilė, Doshi Neel, Sapetschnig Alexandra, Lamond Angus, Ladbury John Edward, Miska Eric Alexander

Abstract excerpt

Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how the PIWI-interacting RNA (piRNA) pathway engages with the membraneless organelle P granule in Caenorhabditis elegans. Proteomic analysis of the PIWI protein PRG-1 reveals an interaction with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32843637
DOI: 10.1038/s41467-020-18089-1
PMCID: PMC7447803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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