Article
Primary piRNA biogenesis: caught up in a Maelstrom.
The EMBO journal - 17 Sept 2014
Pandey Radha Raman, Pillai Ramesh S
Abstract excerpt
Precursors for most Piwi-interacting RNAs (piRNAs) are indistinguishable from other RNA polymerase II-transcribed long noncoding RNAs. So, it is currently unclear how they are recognized as substrates by the piRNA processing machinery that resides in cytoplasmic granules called nuage. In this issue, Castaneda et al (2014) reveal a role for the nuage component and nucleo-cytoplasmic shuttling protein Maelstrom in...
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