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Article

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors.

Neuron - 22 Mar 2017

Chiu Shu-Ling, Diering Graham Hugh, Ye Bing, Takamiya Kogo, Chen Chih-Ming, Jiang Yuwu, Niranjan Tejasvi, Schwartz Charles E, Wang Tao, Huganir Richard L

Abstract excerpt

Learning depends on experience-dependent modification of synaptic efficacy and neuronal connectivity in the brain. We provide direct evidence for physiological roles of the recycling endosome protein GRASP1 in glutamatergic synapse function and animal behavior. Mice lacking GRASP1 showed abnormal excitatory synapse number, synaptic plasticity, and hippocampal-dependent learning and memory due to a failure in...

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Identifiers

PMID: 28285821
DOI: 10.1016/j.neuron.2017.02.031
PMCID: PMC5382714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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