Article

Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more generally, from a history-dependent change in the threshold for plasticity. This hypothesis was based on experimental results from mice lacking t...

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Literature Corpus work: d2ae7039-ef12-512c-aac1-fc558f392b6e
DOI: 10.1101/2023.10.05.561013

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