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Article

Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009

Etherton Mark R, Blaiss Cory A, Powell Craig M, Südhof Thomas C

Abstract excerpt

Deletions in the neurexin-1alpha gene were identified in large-scale unbiased screens for copy-number variations in patients with autism or schizophrenia. To explore the underlying biology, we studied the electrophysiological and behavioral phenotype of mice lacking neurexin-1alpha. Hippocampal slice physiology uncovered a defect in excitatory synaptic strength in neurexin-1alpha deficient mice, as revealed by a...

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Identifiers

PMID: 19822762
DOI: 10.1073/pnas.0910297106
PMCID: PMC2764944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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