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Article

HMGCR-related SNPs and cholelithiasis: statins may exert effects beyond lipid-lowering.

Postgraduate medical journal - 20 May 2026

Qin Da, Wei Qilu, Du Shiyu

Abstract excerpt

BACKGROUND: As traditional lipid-lowering drugs, the role of statins in reducing the incidence of cholelithiasis remains controversial. The aim of this study is to utilize the single nucleotide polymorphisms (SNPs) related to the target of statins, HMGCR, to simulate the effect of statins and explore the causal relationship between statins and cholelithiasis. METHODS: Drug-targeted Mendelian randomization (MR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41378867
DOI: 10.1093/postmj/qgaf222

Genes

HMGCR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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