Article

New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: a drug Mendelian randomization study

2024-04-25

Abstract excerpt

<title>Abstract</title> <p>Primary sclerosing cholangitis (PSC) lacks specific drugs. Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), have shown potential for improving PSC prognosis, but their therapeutic efficacy remains controversial. We analyzed HMGCR single nucleotide polymorphisms (SNPs) from published genome-wide association studies using Mendelian randomization (MR) to asse...

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Literature Corpus work: 5b2bfa33-e41b-52db-9ddd-da46ed5b660a
DOI: 10.21203/rs.3.rs-4262308/v1

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