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Article

HMGCR and ApoE mutations may cause different responses to lipid lowering statin therapy.

Cellular and molecular biology (Noisy-le-Grand, France) - 31 Oct 2017

Kirac D, Bayam E, Dagdelen M, Gezmis H, Sarikaya S, Pala S, Altunok E C, Genc E

Abstract excerpt

Coronary artery disease (CAD) and its complications are the major causes of death in the world. Although statins have been used to lower lipid levels in CAD patients, this goal can not be attained in 1/3 of the patients. The objective of this study was to investigate whether common variations in HMG-CoA Reductase(HMGCR) and Apolipoprotein E (ApoE) genes involved in lipid and statin metabolism modify the effect of...

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Source

Identifiers

PMID: 29096742
DOI: 10.14715/cmb/2017.63.10.6

Genes

HMGCR
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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